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8Aug 2019

Management of ageing skin

BASIC CONCEPT OF CUTANEOUS AGEING

Cutaneous ageing is caused by genetic factors or Intrinsic Ageing and those caused by factors with exogenous Origins or Extrinsic aging.

INTRINSIC AGEING:  Telomeres, the specialized structures found at the ends of eukaryotic chromosomes, are now believed to plan an essential role in the intrinsic ageing process at the cellular level. Intact telomeres are integral in extending the life span of the cells. With age, telomere length shortens thereby triggering the skin ageing process. The natural, progressive shortening of telomeres may be one of the primary mechanisms of cellular ageing in skin. Telomeres and other constituents also sustain low grade oxidated damage as a result of aerobic cellular metabolism which further contributes to intrinsic ageing.

EXTRINSIC AGEING: This is largely induced by nature(sun) and by factors with clearly exogenous origin like smoking and poor nutrition. Sun exposure is the main cause of extrinsic premature cutaneous ageing. Moreover it is believed to account for 80% of facial ageing.

CHARACTERISTICS OF AGEING SKIN:

Ageing changes are seen in all the layers of the skin, right from the epidermis, dermis to the subcutaneous layer. Changes in the dermis are more pronounced than changes in the epidermis.

CHANGES IN THE EPIDERMIS:

The thickness of stratum corneum does not change very much with age but, the spinous layer of wrinkle is thinner and contains fewer keratohyalin granule.The dermal epidermal junction(DEJ) is known to be flattened with a reduced connecting surface area. Between the third and eight decades of life, the epidermal turnover rate slows down by 30%-50%.

CHANGES IN DERMIS:

Approximately 20% of dermal thickness disappears as people age. Aged dermis becomes relatively Acellular and Avascular. Changes in collagen production and development of fragmented elastic fibers also characterize normal aged dermis. Photo aged dermis exhibits disorganized collagen fibrils and an accumulation of abnormal elastin containing material. The collagen fibers get thickened and are wrapped in rope-like bundles, quite in homogeneous compared to younger skin.

GAG, particularly hyaluronic acids (HA) are reduced in photo aged skin. The decreased in HA levels contributes to its disassociation from collagen and elastin as well as reduced water binding and maybe involved in changes noted in ageing skin including wrinkling, altered elasticity, reduced turgidity, and diminished capacity to support the microvasculature of the skin. Aged skin has been shown to be relatively avascular.

CHANGES IN SUBCUTANEOUS TISSUE

Site specific changes, including gains and losses are known to occur in subcutaneous tissue that also influences the appearance of elderly skin. Subcutaneous fat diminishes in the face, dorsum of the hands and the shins, whereas there is an increased fat bulge around the waste in women and abdomen in men.

MANAGEMENT OF AGEING SKIN
(A) SKIN PROTECTION
(B) MEDICAL INTERVENTION ( treatments with drugs and natural compounds)
(C)  COSMETIC DERMATOLOGICAL REJUVENATION PROCEDURES
  • Chemical peels
  • Resurfacing techniques
  • Laser System
  • Radio frequency technology
  • Botulinum toxins
  • Soft tissue augmentation
(D)  PHYSICAL & CHEMICAL MEDICAL & SURGICAL TREATMENT FOR SURFACE TEXTURAL CHANGES
 (A)  SUN PROTECTION

Perhaps the single most cost-effective therapy that can be offered to patients is sun protection. In the form of sun avoidance, sun protective clothing and sun screens. Peak time for UV exposure is between 10.00 am to 4.00 pm and sun avoidance should be encouraged during this time.

(B) MEDICAL INTERVENTION

Medical intervention in the form of certain topical and oral agents would help in delaying and or preventing extrinsic ageing. The agents that can be used for:

Retinoid:

  • Tretinoin
  • Retinos
  • Tazarotene

Antioxidants:

  • Topical and oral Vitamin C
  • Oral antioxidant supplements
  • Coenzyme Q 10
  • Alpha lipoic acid

AHA’s Hormonal Replacement:

  • Topical estrogen
  • Systemic estrogen

Growth factors, Cytokines

Newer Compounds

  • Peptides
  • FROP-3
  • Date Pame cernel extracts
(C)  COSMETIC DERMATOLOGICAL REJUVENATION PROCEDURES

CHEMICAL PEELS

Various medium depth and deep chemical peels are used to improve the sun damaged textural changes and also to help promote neocollagenesis. These are simple cost effective and in office techniques which are widely used as anti-ageing rejuvenating procedures.

RESURFACING TECHNIQUES

  • Microdermabrasion
  •  Microcoblation

LASER SYSTEMS

ABLATIVE DEVICES

The two traditional ablative devices which have been used for Carbon dioxide laser (Co2) and erbium YAG Laser.

THE Co2 laser has been the gold standard for ablative re-surfacing. Results from traditional Co2 systems have dramatic for severe photo damaged skin but patients need to aware of associated down time requirements and the risk of pigmentation alteration in darker skin types.

Newer Technologies including the Erbium YAG systems, fractional lasers and plasma skin regeneration devices can treat a variety of cutaneous disorders while offering shorter recovery times and improved safety in a broader spectrum of skin types.

All ablative options can address photo ageing, pigmentary disturbance and acne scarring. In general laser skin resurfacing provides the greatest depth of ablation and is an excellent option for severe photo ageing. Indications include moderated to severe rhytides and photo damage, scarring, actinic keratosis and other superficial lesions. Fractional ablative laser produce rejuvenation and collagen remodeling by creating thousands of microscopic wounds called microscopic treatment zones ( MTZ’s) with sparing of adjacent skin indicated in mild to moderate photo damaged skin.

Plasma skin rejuvenation delivers plasma energy into the dermis while leaving the skin surface intact leading to neo-epithelialization and collagen synthesis. Indications are similar to fractional ablative lasers.

NON ABLATIVE LASERS AND LIGHT SOURCES

Non ablative lasers heat the papillary and reticular dermis, without damaging the epidermis to stimulate collagen synthesis. Compared with ablative procedures, non-ablative resurfacing provides more modest improvement but with essentially no downtime and excellent safety profile. Non ablative lasers can be divided into the following categories

  • Devices targeting pigment lesions
  • Devices targeting vascular lesions
  • Devices targeting water
  • Combination devices

The three biological significant chromophores are hemoglobin, melanin and water. Non ablative rejuvenation is better defined as target specific rejuvenation and non-ablative skin re-modeling and is targeted to three goals; reduction in vascular anomalies, pigment anomalies and improvement static fine rhytides.

RADIO FREQUENCY TECHNOLOGIES
  • Monopolar radio frequency thermage thermacool
  • Bipolar radio frequency and light sources Elos technology
  • Monopolar and bipolar combination radio frequency Alma accent

The best candidates for radio frequency skin tightening include younger patients, patients with mild laxity and those with mild to moderate amounts of facial adipose.

BOTULINUM TOXINS

In an attempt to delay skin damage, the causes responsible for ageing mainly elastic and collagen fiber degradation, gravity force and mimetic muscles which act on facial expressions with dynamic or hyper kinetic wrinkles lines due to their frequent muscle activation have to be targeted.

Botulinum toxins weakens the overactive underlying muscle contraction causing flattering of the facial skin and also improves cosmetic appearance. BTX-A injections are very well tolerated low invasive, non-surgical method to treat hyper kinetic wrinkles. The effect, although temporary is extremely popular with patients, has a low incidence of side effects and is relatively easy technique to learn.

SOFT TISSUE AUGMENTATION

The placement of high flow, low viscosity materials for soft tissue enhancement has a long history of use in aesthetic facial alteration. The past 5- 10 years has seen the emergence of numerous new fillers of differing compositions. When combined with increasing popularity of injectable botox and other office-based procedures the role of injectable soft tissue augmentation continues to expand in the management of ageing skin.

The injectable soft tissue fillers can be divided as follows:

  • Collagen stimulation & Volume Restoration
  • Poly-L-Lactic acid (Sculptra)
  • Calcium Hydroxyapatite (Radiesse)
(D)  PHYSICAL & CHEMICAL MEDICAL & SURGICAL TREATMENT FOR SURFACE TEXTURAL CHANGES

With age, the appearance and surface texture of skin can change dramatically as represented by the development of acrochordons (Skin tags). Cherry angiomas, seborrheic keratoses, lentigos (sun spots) and sebaceous hyperplasia’s , amongst other lesions cutaneous alterations which are removed via physical or chemical medical and surgical treatment.

CONCLUSION

It is important to have an excellent concept of the three dimensional aspect of the face and neck and how the various above mentioned treatment modalities could be used as a monotherapy or combination treatment to achieve a desirable overall effect. Remind the patient that they will continue to age, breaking down collagen as well as being subjected to the forces of gravity, It is also important to make sure that they take responsibility for skin care, including high-grade cosmeceutical or Pharmaceutical preparations known to stimulate collagen synthesis, as well as practicing excellent sun protection to protect their investment they have made in their skin.